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Metastasis is the leading cause of breast cancer-associated deaths. Consequently, a deeper understanding of the metastasis biology is key to developing better treatment strategies and achieving long-lasting therapeutic efficacies against breast cancer. This review covers recent breakthroughs in the discovery of various metastatic traits that contribute to the metastasis cascade of breast cancer, which may provide novel avenues for therapeutic targeting.

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Search for the other articles from the author in: Google Scholar PubMed. Total Citations. Submitted: Apr 3, Published: Mar 31,

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Breast cancer metastasis accounts for the majority of deaths from breast cancer. Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients.

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Though we refer to it as simply breast cancer, like many diseases, breast cancer comes in several types that grow and respond to medicines differently. All breast cancers start in the tissues of the breast, when breast cells grow out of control. This happens because of a mutation error in cell DNA that causes them to reproduce without stopping, making the cells become malignant, or cancerous.

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Metastatic breast cancer is also classified as Stage 4 breast cancer. The cancer has spread to other parts of the body. This usually includes the lungs, liver, bones or brain.

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Secondary breast cancer occurs when breast cancer cells spread from the first primary cancer in the breast through the lymphatic or blood system to other parts of the body. Secondary breast cancer is not the same as breast cancer recurrence. If you are concerned about your breast cancer returning, you can find information and support.

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Correspondence Address: Dr. D'Angelo Francesco, U. E-mail: francesco.

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Most women with stage IV breast cancer are treated with systemic therapy. This may include hormone therapy, chemotherapy, targeted therapy, or some combination of these. Local treatments such as surgery or radiation might also be used to help prevent or treat symptoms. Stage IV cancers have spread beyond the breast and nearby lymph nodes to other parts of the body.

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A diagnosis of metastatic breast cancer MBC can feel overwhelming. However, you should know that many young women have heard the same diagnosis as you and continue to live full lives today. Metastatic Breast Cancer MBC is breast cancer that has left the breast and nearby lymph nodes and has been found in other parts of the body.

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Metastatic breast cancer also called stage IV or advanced breast cancer is not a specific type of breast cancer. It's the most advanced stage of breast cancer. Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other organs in the body most often the bones, lungs, liver or brain. For example, breast cancer that has spread to the bones is still breast cancer not bone cancer.


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